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KMID : 0369319940140020253
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Allergy
1994 Volume.14 No. 2 p.253 ~ p.257
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A Case of Bronchospasm after Intravenous Solu-Cortef Infusion in an Asthmatics
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한표성
홍석철/이종진/조해정/김주옥/김선영
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Abstract
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Corticosteroids are widely used in the treatment of bronchodilator -resistant bronchial asthma and various forms of anaphylaxis because of their antiinflammatory and immunosuppressive properties. Since Hollander reported 4 cases of urticaria out
of
a
total of 10,000 intra-articular injections of hydrocortisone in 1953, several cases of bronchospasm with urticaria and angioedema after intravenous corticosteroids infusion have been reported
We recently experienced a case of bronchospasm after intravenous Solu-Cortef(Solu-Cortef, the Upjohn co., Kalmazoo, Mich.) infusion to 24 year-old female asthmatic patient with aspirin hypersensitivity for the purpose of symptom relief. After
intravenous administration of Solu-Cortef 125mg, she complained tachypmea, severe dyspnea, and coughing with chest tightness. Several minutes later, cyanosis appeared. Two times of subcutaneous epinephrine (1:1,000, 0.3cc) injections and manual
bagging
with endotracheal intubation were done. She was stabilized by mechanical ventilation 150 minutes after the attack of bronchospasm. And then she was admitted to ICU for mechanical ventilatory care.
In was suggested that the bronchospasm be caused by intravenous Solu-Cortef infusion. Therefore, we emphasize the history taking of any corticosteroid hypersensitivity before it´s clinical use.
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